4′-(Morpholinomethyl)biphenyl-2-carbonitrile
نویسنده
چکیده
In the title compound, C(18)H(18)N(2)O, the morpholine ring adopts a chair conformation and the dihedral angle between the aromatic rings is 49.16 (7)°. In the crystal, weak C-H⋯π inter-actions may help to establish the packing.
منابع مشابه
PVT Measurements on 4'-w-Hexyl-Biphenyl-4-Carbonitrile (6CB) and 4 -w-Heptyl-Biphenyl-4-Carbonitrile (7CB) up to 300 MPa
P, Vm, 7" data were established for 4'-n-hexyl-biphenyl-4-carbonitrile (6CB) and 4'-n-heptyl-biphenyl-4-carbonitrile (7CB) between 300 and 370 K up to 300 MPa, and specific volumes were determined for the liquid crystalline, isotropic, and also partly for the crystal phases. Volume and enthalpy changes at the phase transitions are also presented. In the case of 6CB, a new crystal phase has been...
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In the crystal structure of the title compound, C(18)H(19)N(2)O(+)·BF(4) (-), bifurcated N-H⋯(F,F) hydrogen bonds link the protonated 4'-morpholine-methyl-biphenyl-2-carbonitrile cations and slightly distorted tetra-fluoro-borate anions. π-π inter-actions [centroid-centroid distance = 3.805 (3) Å] help to consolidate the packing. The dihedral angle between the benzene rings in the cation is 57....
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Development of efficient commercial process for the preparation of highly pure 4'-(2-Butyl-4-oxo-1,3-diazaspiro[4,4]non-1-en-3-ylmethyl)-biphenyl-2-carbonitrile (1), an advanced intermediate of Irbesartan is described. The developed process minimizes the impurity formation and utilizes the simplified process to improve yield, throughput and is suitable for production on commercial scale.
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